Ameliorative Effect of Moringa oleifera Lam. Leaves Extract on the Sex Hormone Profile and Testicular Dysfunctions in Streptozotocin-induced Diabetic Wistar Rats

Pharmacognosy Research,2022,14,2,225-232.DOI:10.5530/pres.14.2.32Published:April 2022Type:Original ArticleAuthors:Ram Niwas Jangir, and Gyan Chand Jain Author(s) affiliations:Ram Jain* Department of Zoology, University Rajasthan, Jaipur, INDIA. Abstract:Background: Diabetes mellitus (DM) is associated with reproductive impairment. Medicinal plants herbs are the rich source antioxidants which may ameliorate diabetes?induced male dysfunctions could play an important role in management diabetes induced infertility. Objectives: The present study aimed to investigate ameliorative effects 70% hydroalcoholic extract Moringa oleifera Lam. leaves on sex hormone alterations testicular dysfunction diabetic rats. Materials Methods: rats was by single intraperitoneal injection streptozotocin (60 mg/kg b.wt.). were treated three different doses (100, 250, 500 b.wt./day, orally for 60 days) M. extract. results compared reference antidiabetic drug glibenclamide (5 b.wt./day) Reproductive hormones like testosterone, FSH LH oxidative stress parameters tissues determined. Histopathological histomorphometric changes testis also investigated. Results: Oral administration or significantly improved serum levels restored histopathological as control Furthermore, treatment reduced TBARS antioxidant markers tissue. These comparable glibenclamide. Conclusion: Based these results, it be concluded that possess significant activities well a pivotal modulating Key words: Antioxidants, Histomorphometric, oleifera, Streptozotocin, Testis, Testosterone, View:PDF (569.11 KB)